Find answers about XEMBIFY, primary humoral immunodeficiency disease, immune globulin therapy, and more

XEMBIFY is a 20% subcutaneous immune globulin (SCIG) replacement therapy used to treat PI (primary humoral immunodeficiency disease) in patients 2 years of age and older.

Learn more about why XEMBIFY may be right for you with our Xplainer video series:

Subcutaneous immune globulin (SCIG) is administered just under the skin, while intravenous immune globulin (IVIG) therapy is administered through a vein. Different IG products have different concentrations. This means they may require more or less volume to be infused. XEMBIFY is a 20% SCIG replacement therapy used to treat PI in patients 2 years of age and older.

Learn more about IG therapy and how to prepare for conversations with your healthcare team. Download the guide now.

XEMBIFY is a subcutaneous immune globulin (SCIG) replacement therapy used to treat PI in patients 2 years of age and older. XEMBIFY can only be administered by subcutaneous infusion. Some patients infuse XEMBIFY as often as every day, while other patients infuse once per week. Talk to your doctor about your infusion schedule.

Hear Joanne, who is a retired nurse with PI, describe her experience with XEMBIFY and how she learned about self-infusion.

XEMBIFY is made from human plasma that is donated by healthy people. It contains antibodies collected from these healthy people that replace the missing or ineffective antibodies in PI patients. The plasma is purified through a unique manufacturing process known as caprylate/chromatography, which results in a product with a maximum percentage of IgG protein to fight infections.

No, XEMBIFY contains no preservatives.

In a clinical study, people taking XEMBIFY saw improvement in their symptoms of PI and the impact PI had on their lives. Within a year, people taking XEMBIFY experienced:

• 0 serious bacterial infections^1*†
• Fewer than 3 days of missed work/school due to infections¹
• 0 hospitalizations due to infections^1†

*One patient reported sepsis due to an animal bite, an event deemed unrelated to the treatment.
^†Rate per subject-year: 0.049.

The most common side effects in a clinical study with PI patients who received XEMBIFY were²:

• Infusion-site reactions such as redness, pain, puffiness, swelling, bruising, nodule or scab formation, itching, and firmness
• Cough and diarrhea
  • Side-effect rates for cough and diarrhea were low, with only 4 events of cough per 1000 infusions and 3 events of diarrhea per 1000 infusions

Tell your healthcare provider if you have or ever had:

• A serious reaction to other medicines that contain immune globulin
• An immunoglobulin A (IgA) deficiency
• A history of heart or blood vessel disease
• Blood clots or “thick blood”
• Inability to move for some time

It is not known whether XEMBIFY can cause fetal harm when administered to a pregnant woman or if it can affect reproduction. Talk to your doctor if you are pregnant or may become pregnant.

Most patients or caregivers can be trained to infuse. However, self-administration should be done only after you go through self-infusion training with a healthcare professional. Your specialty pharmacy will provide nurse support to train you to infuse.

You can ask your healthcare provider questions about self-administration, especially if you need a refresher or if your infusion schedule has recently changed. Learn more about how to infuse XEMBIFY.

Yes. It's important to work with your healthcare provider when receiving SCIG therapy. Regular healthcare provider visits are an important part of getting the most out of treatment. At each visit, your healthcare provider will review your treatment regimen, evaluate your response to treatment, and address any concerns you may have. It's important to bring your Infusion Log Book with you when you visit your healthcare provider.

If you receive your product and supplies through a specialty pharmacy, they will provide your supplies for infusing XEMBIFY, including an infusion pump, needle set(s), and tubing. Both your specialty pharmacy nurse and healthcare provider can explain your equipment choices, how to use your supplies (including needle size), and how to infuse XEMBIFY.

You can also access the infusion-related resources included in the XEMBIFY Patient Starter Kit. Learn more about infusion resources.

XEMBIFY may be given in 1 to 6 infusion sites with guidance from a healthcare provider. Most patients in the XEMBIFY clinical trials used 4, although fewer may also be used.

For additional information about infusing XEMBIFY, a dedicated team is ready to answer your questions. Contact Xembify Connexions at: 1-844-MYXEMBIFY (1-844-699-3624) Monday through Friday, 8 AM to 8 PM ET. Learn more about what is available through Xembify Connexions or contact your specialty pharmacy.

Xembify Connexions is a patient support program designed to provide strong support right from the start. The Xembify Connexions team can help answer your questions about insurance, copays, financial support, educational resources, and more. Contact Xembify Connexions for more information: 1-844-MYXEMBIFY (1-844-699-3624) Monday through Friday, 8 AM to 8 PM ET.

Xembify Connexions offers savings of up to $10,000 per calendar year for eligible patients (subject to terms and conditions). With copay support, you may be eligible to pay $0 out of pocket. It covers copayments, deductibles, and coinsurance and is available whether the claim is billed under a pharmacy benefit or a medical benefit. What's more, there are no monthly caps or infusion limits.

Xembify Connexions will work with your insurance provider to help you better understand your coverage. You may be qualified to receive XEMBIFY at no cost in the event you lose your insurance coverage. Contact Xembify Connexions for more information: 
1-844-MYXEMBIFY (1-844-699-3624) Monday through Friday, 8 AM to 8 PM ET.

If you do not have insurance coverage, you may be eligible to receive XEMBIFY at no cost. Contact Xembify Connexions for more information: 1-844-MYXEMBIFY (1-844-699-3624) Monday through Friday, 8 AM to 8 PM ET.

Yes, you need to enroll in the Xembify Connexions program to be eligible for copay assistance for XEMBIFY. This allows the program to receive your insurance information and set up your copay assistance so you can seamlessly access your therapy. Xembify Connexions will help you understand the coverage and support available to you and can work with your specialty pharmacy to ensure you receive your medication.

Beyond helping you understand your copayments, deductibles, and insurance coverage, Xembify Connexions provides ongoing support, including educational information and resources to address your healthcare needs.

Learn more about what is available through Xembify Connexions by calling 1-844-MYXEMBIFY (1-844-699-3624) Monday through Friday, 8 AM to 8 PM ET, or by contacting your specialty pharmacy.

PI stands for primary humoral immunodeficiency disease. There are more than 450 different kinds of PI³. When you have PI, part of your immune system, which is what protects you from infections and fights off diseases, is missing or doesn’t function properly. As a result, your body can't protect you from germs as well as it should, so you are more likely to develop infections and be sick more often.³ Learn more about PI.

Hear Joanne, a PI patient and retired registered nurse, describe her journey to getting diagnosed with PI.

Primary immunodeficiency disorders occur when parts of the immune system (such as certain cells ​or antibodies) are either not working properly, too low, or missing altogether.^3,4

The signs and symptoms of PI vary from person to person. The most common symptoms include^3,4:

• Chronic, recurring infections that are more severe, longer lasting, and more difficult to cure, such as sinus infections, when compared to people with healthy immune systems
• Frequently getting sick with infections, such as a common cold, that a healthy immune system would normally be able to fight off
• Autoimmune problems, such as autoimmune lung or skin disease, which happen when the immune system attacks the body's own organs. Other issues include anemia, celiac disease, arthritis, lupus, and thyroid disorders⁴

PI is not contagious; you can't catch it from someone else. PI is usually inherited, which means it is carried through the genes of your parents. If you have the disease, you might pass it along to your children, but you won't give it to anyone else.⁴

There are more than 450 types of PI.³ For disorders that affect antibody production, doctors may recommend immune globulin replacement therapy.¹  Over-the-counter drugs, such as aspirin, decongestants, and/or expectorants are, used to treat symptoms. Antibiotics are also used to treat infections and deal with a wide range of germs that have a greater impact on people with PI.⁴

Other treatments may also be available.⁴

Immune globulin, or IG, is a medicine made from proteins from human plasma taken from healthy donors and contains purified antibodies. Plasma is the liquid part of the blood that contains antibodies needed to keep the body healthy.

Immune globulin is given to people with PI to replace missing or ineffective proteins to help the immune system protect against germs and other threats. It is sometimes referred to as IG replacement therapy.

Learn more about IG therapy and how to prepare for conversations with your healthcare team. Download the guide now.

Subcutaneous immune globulin (SCIG) is administered under the skin, while intravenous immune globulin (IVIG) therapy is administered through a vein. Different IG products have different concentrations. This means they may require more or less volume to be infused. XEMBIFY is an SCIG replacement treatment used to treat PI in patients 2 years of age and older.

Learn more about IG therapy and how to prepare for conversations with your healthcare team. Download the guide now.